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For specialists working in the pharmaceutical and herbal fields

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J PharmPharmacognRes 3(6): 162-170, 2015.
Sección Análisis de Drogas, Instituto de Salud Pública de Chile;
Sección Química de Alimentos, Instituto de Salud Pública de Chile. Avenida Marathon 1000, Santiago,Chile
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Context : Consumption of synthetic drugs had increased in recent years, used as a recreational drug by young people who presume that consumption of this drug is harmless for health; however clinical studies have shown that this stimulant and its metabolites are toxic. Due to these reasons, chemical analysis of this illicit drug is crucial from the points of view of occupational medicine, toxicology, and law enforcement with the aim of pursuit the traffic of illegal drug.

Aims : Implement and fully validate a rapid and simple method for detection and quantitation of MDMA by High-Performance Thin Layer Chromatography in seized samples.

Methods : With the implemented method was analyzed 12 positive samples seized by Chilean police, to found the concentration of MDMA in ecstasy tablets.

Results : The method was fully validated, the linearity of the method was evaluated by the calibration curve between 51.0 – 510.0 µg/band (R 2 0.9977); limit of detection was 12.1 µg per band, and limit of quantitation was 36.8 µg per band. The precision of the method (RSD) was lower than 5.0%. Accuracy was evaluated by determination of the percentage of MDMA recovered by the assay (99.13%), and relative Uncertainty was 6.66%. With this method, it was analyzed real seized samples of MDMA, results showed that all samples contained MDMA and concentration was between 18.15 – 59.84 % w/w.

Conclusions: The method is selective, sensitive, and specific, with possible application in forensic analysis. To the best of our knowledge, this is the first report about concentration of MDMA in ecstasy pills in Chile.

Keywords : 3,4-methylenedioxymethamphetamine; ecstasy; HPTLC; MDMA.

Contexto: El consumo de drogas sintéticas se ha incrementado en los últimos años. Estas son utilizadas principalmente por jóvenes quienes asumen que su consumo es inofensivo para la salud; sin embargo, estudios clínicos han demostrado que, particularmente el MDMA y sus metabolitos, son tóxicos. Debido a estas razones, el análisis químico de esta droga ilícita es muy importante desde el punto de vista de la toxicología, medicina forense y en la aplicación de la ley con el propósito de perseguir el tráfico ilícito de drogas.

Did you know that nearly 75% of people who add something to an online shopping cart abandon the website instead of making the purchase?

Whether it’s a shopping cart, a web form, or some other type of online conversion you are pushing, the fact remains that most people who visit the page will not convert.

So how can we leverage these “abandoners” into more conversions and sales?

The answer is remarketing.

How Remarketing Works

Adwords Remarketing works by tracking when somebody performs a specific action, such as visiting your website. A cookie is placed on their computer that makes note of this activity. When this person goes to other websites, they will then see your image or text ad follow them around the web. This method allows you to heavily target people who have shown some level of interest in your company or product. Once you create the audience in Google Analytics, you can import it to Adwords. Beyond the basic setup and strategy, there are lots of advanced tactics that you can utilizeto make your remarketing campaigns work even better.

Audience Segmentation

(Who do you want to target?)

Page Filtering

The first way to define an audience is to filter all your users by the pages they visit on your website. You can make this relatively broad, like in this image below, selecting anyone who has visited one category of pages. Or you can get more specific by selecting users who visit, for example, page X and not page Y. This is how you would create the “abandoners” audience (users who visited the shopping cart page but didn’t visit the order confirmation page).

Demographic Filtering

One option to fine-tune your remarketing list is with demographic filtering.The basic options are age, gender and language. If you want to get more advanced you can target based on affinity categories. One example would be “movie lovers”. These are people towards the top of the funnel who have shown some sort of affinity for a topic related to your business. Another option is in-market segments, which allows you to validate that your users are actually interested in purchasing your products. These users are towards the end of the sales funnel. It’s important to note that these filters are very specific, and if youdon’t have a lot of traffic to your site, you will see the audience size shrink quickly while applying them.

Technology Filtering

Another option is to filter by technology. This gives you the option to filter by anoperating system, browser, device, screen resolutions, and more. There is also an option to filter all mobile devices, including tablets.

Behavior Filtering

Yet another option is to filter by behavior. What this means is the number of sessions a user has had on your website. You can also look at days since last session, transactions and session duration.

Combinations (Sequence, Conditional)

This is where things start to get advanced. You can get as hyper-specific as you wantby building an audience with sequence or conditional logic. For example, you could target people aged 25-34 who visited your contact us page more than once on a mobile device (including tablets). Once you apply the audience, Google will give you an estimate of the number of users over the past 7 days who fit all of your criteria. If the number is really small, you might be getting too specific. You can see our audience over the last 7 days in the image below is 21.

Limit Settings

(When should you stop targeting them?)

Member Duration

Once you’vedecided who you want to remarket you, the next step is to decide on how long someone stays on this list. The default membership is 30 days, however this will vary based on your business. If your customers take a long time to decide whether or not to purchase, you may want to increase it. If you’re worried about people getting annoyed by seeing your ads everywhere, you may want to decrease it.

Frequency Capping

Another configuration setting, frequency capping allows you to set a limit, or cap, to the number of ads one particular person will see over their membership on your list. This can also help you avoid the problem of people seeing your ads too often.

More Advanced Tactics

(How else can we increase conversions with remarketing?)

RLSA

Remarketing Lists for Search Ads allows you to perform the same remarketing tactics, but instead of showing up on the display network, these text ads show up in search results. Here are a few advanced tactics specifically for RLSA:

The one caveat with RLSA is that you need the audience to reach 1,000 members before remarketing ads will run on the search network. Depending on how much traffic your website gets, this could take anywhere from a few days to a few months to build. Watch a 2-minute video to get a better understanding on RLSA.

Source Remarketing

This advanced tactic allows you to build remarketing audiences based on the traffic source that they initiallycame to you from. One great example is building a list of traffic that comes from Linkedin. Typically, Linkedin traffic is very high value and normally costly to advertise on. But with source remarketing, we can get ads in front of these people at a much lower cost!

Customer Match

One last strategy is to build customer matchaudiences and remarket to them. This audience is actually built in Adwords under shared library>audiences. You build the audience by uploading a CSV file of all of your customers’ email addresses. You can then set a membership duration, which should typically be longer since you aren’t as likely to bother people who are your customers.

Feel free to contact us to discuss how remarketing could help increase your online conversions and sales.

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610-431-3500 sales@diplomatclosetdesign.com Southeastern Pennsylvania

Specializing inboth simple closet systems to fully custom built-in designs. We’ve been reorganizing Southeastern PA since 2010.

Our Skillset

Over the past eight years, Diplomat Closet Design has evolved into one of the premier custom closet manufacturers in all of Southeastern Pennsylvania. From machine operators to shop-hands to our skilled carpenters, designers, and install teams, we will make your experience a professionalone, start-to-finish.

Projects We've Completed

The fact that we employ only highly skilled carpenters allows us to take on projects anywherein your house. Despite the name, we are much more than just closets! Here are some of the other areas of the house we work on; BASEMENTS, GARAGES, HOME OFFICES, PANTRIES, LAUNDRY ROOMS, ENTERTAINMENT SPACES, MUDROOMS, HOBBY ROOMS, and even KITCHENS .

Why We Love What We Do

We’ve been on a collective mission to rid the world of horrible wire shelving, heinous builders grade shelving, messy garages, unorganized work spaces, and underutilized storage areas! And our mission is simple: be honest with the customer, delivery a quality product on time, and leave the customer 100% satisfied.

Callusat 610-431-3500 or visit our Contact Page .

Hear from our past clients

I worked with Diplomat Closet Design for my Master Bedroom closet. I shopped around quite a bit trying to find the best quality for an affordable price. I heard about Diplomat from a close friend who recently had a great experience! The consultation was very easy to schedule and didnt take long either. They were able to quickly discuss my needs, take measurements, and shortly therafter produced a digital mock up of a design specific to my needs. The install was easy and quick and the results are amazing! They were affordable, easy to work with, informative, and my new closet has exceeded my expectations. I am now discussing a second closet with them for my spare bedroom! I would absolutely refer them to friends and family, and already have!

We had a wonderful experience with Diplomat Closet Design. WOW!!! Our closet is amazing now. They custom built us the most incredible closet system one could ever want. Ryan Lindstadt (owner) came up with four different design plans (all in 3-D so it was super easy to visualize). He was extremely professional, courteous, and always got back to me when I had a question. Ryan and his team, Tim and Kevin, did a super job building it, and everything was absolutely perfect. Words really can't describe how awesome our closet system is. Oh, and the price was very very reasonable. Super high quality materials, super high quality craftmanship, and super price. We couldn't have asked for more. Seriously.

We were in the market for closet systems for a master closet, our baby's closet and a simple garage storage solution. We had several quotes, but Chris from Diplomat went above and beyond our expectations and made our choice easy (not the lowest quote either). He was on time for appointments, provided detailed sketches of each room and was very knowledgeable. Our wishlist for the master was long and put us over what we wanted to spend, but he was able to suggest a few minor changes to lower the cost and get us much closer to our budget! We've suffered with wire shelving since we moved in and it was a big step to invest in closet systems... needless to say it was WELL worth every penny and couldn't be happier with the choice we made to go with Diplomat!

A co-worker recommended Diplomat Closet Designs to me and I am so happy he did. I really enjoyed working with this team! They installed a well-designed, quality system for my woman cave. I now have a very pretty, very efficient walk in closet, and all at a very reasonable price. Chris and Ryan were so pleasant to work with, they provided a layout that covered all my needs. Kevin and Tim did a wonderful job with the install. From start to finish, this team and process was great! I have already asked to them to work on another walk-in closet in our home. Thank you so much Diplomat Closet Design!

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Development Bank of Wales Plc (Banc Datblygu Cymru ccc) is the holding company of a Group that trades as Development Bank of Wales. The Group is made up of a number of subsidiaries which are registered with names including the initials DBW. Development Bank of Wales Plc is a development finance company wholly owned by the Welsh Ministers and it is neither authorised nor regulated by the Prudential Regulation Authority (PRA) or the Financial Conduct Authority (FCA). The Development Bank of Wales (Banc Datblygu Cymru ccc) has three subsidiaries which are authorised and regulated by the FCA. Please note that neither the Development Bank of Wales Plc (Banc Datblygu Cymru ccc) nor any of its subsidiaries are banking institutions or operate as such. This means that none of the group entities are able to accept deposits from the public. A complete legal structure chart for Development Bank of Wales Plc can be found here. DBW (10) Investments Limited is authorised and regulated by the Financial Conduct Authority for credit-related regulated activities.